Background
TECHNOLOGY

Image Scanning Microscopy

Discover next-generation confocal microscopy

Image Scanning Microscopy (ISM) can improve the effective spatial resolution of conventional confocal laser scanning microscopy to its theoretical limit, without compromising any of its functionalities.

Our team implemented a natural design of ISM based on a fast single-photon detector array which allows straightforward upgrade of confocal microscopy and provides access to the raw scanned images, also paving the way to adaptive reconstruction methods.

While standard all-optical implementations of ISM can reduce versatility, our solution enables for a direct combination with fluorescence spectroscopy techniques, such as fluorescence lifetime imaging and fluorescence correlation spectroscopy.

INCREASED
SPATIAL
RESOLUTION


Push confocal microscopy resolution to its theoretical limit by achieving a 2-fold improvement.
PRISM application 1

GENTLER
LIVE-CELL
IMAGING


Achieve the same resolution as ideal confocal at one-tenth the illumination intensity.
PRISM application 2

SUPER
RESOLUTION
FLIM


Collect photons in time-tag modality in order to perform super-resolution time-resolved imaging.
PRISM application 3